| First Author | Matzuk MM | Year | 1992 |
| Journal | Nature | Volume | 360 |
| Issue | 6402 | Pages | 313-9 |
| PubMed ID | 1448148 | Mgi Jnum | J:3315 |
| Mgi Id | MGI:51828 | Doi | 10.1038/360313a0 |
| Citation | Matzuk MM, et al. (1992) Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360(6402):313-9 |
| abstractText | The inhibins are alpha:beta heterodimeric growth factors that are members of the transforming growth factor-beta family. To understand the physiological roles of the inhibins in mammalian development and reproduction, a targeted deletion of the alpha-inhibin gene was generated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the null allele (inhibin-deficient) initially develop normally but every mouse ultimately develops mixed or incompletely differentiated gonadal stromal tumours either unilaterally or bilaterally. Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity. |
