| First Author | Mock BA | Year | 1989 |
| Journal | J Immunol | Volume | 142 |
| Issue | 4 | Pages | 1372-6 |
| PubMed ID | 2563387 | Mgi Jnum | J:9598 |
| Mgi Id | MGI:58057 | Doi | 10.4049/jimmunol.142.4.1372 |
| Citation | Mock BA, et al. (1989) The murine Il-6 gene maps to the proximal region of chromosome 5. J Immunol 142(4):1372-6 |
| abstractText | Murine Il-6 cDNAs were isolated by cross-hybridization with a human IL-6 cDNA from an IL-1 activated bone marrow stromal cell line (W20). Mouse-hamster somatic cell hybrids were utilized to localize murine Il-6 to chromosome 5. Genetic mapping with respect to En-2, AlbH, and Gus in backcross progeny from an interspecific mating between C57BL/6J and Mus spretus positioned Il-6 3 cM distal to En-2. The syntenic relationships of Il-6 and En-2 in mouse and man, as well as the potential role of IL-6 in tumorigenesis, are discussed. |
