| First Author | Crackower MA | Year | 1999 |
| Journal | Genomics | Volume | 55 |
| Issue | 3 | Pages | 257-67 |
| PubMed ID | 10049579 | Mgi Jnum | J:53212 |
| Mgi Id | MGI:1331523 | Doi | 10.1006/geno.1998.5665 |
| Citation | Crackower MA, et al. (1999) Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. Genomics 55(3):257-67 |
| abstractText | Cytoplasmic dynein is a large multisubunit microtubule-based motor protein, which mediates movement of numerous intracellular organelles. We report here the identification of the human homologue of cytoplasmic dynein intermediate chain 1 gene (DNCI1) located on human chromosome 7q21.3-q22.1. The mouse orthologue (Dnci1) was identified along with another highly related gene, Dnci2, and their RNA in situ expression patterns were examined during mouse embryogenesis. Dnci1 was found to have a highly restricted expression domain in the developing forebrain as well as the peripheral nervous system (PNS), while Dnci2 displayed a broad expression profile throughout the entire central nervous system and most of the PNS. A dynamic expression profile was also found for Dnci2 in the developing mouse limb bud. The data presented here provide a framework for the further analysis of the functional role of Dnci1 and Dnci2 in mouse and DNCI1 in human. |
