| First Author | Kato H | Year | 2005 |
| Journal | Immunity | Volume | 23 |
| Issue | 1 | Pages | 19-28 |
| PubMed ID | 16039576 | Mgi Jnum | J:100539 |
| Mgi Id | MGI:3588816 | Doi | 10.1016/j.immuni.2005.04.010 |
| Citation | Kato H, et al. (2005) Cell type-specific involvement of RIG-I in antiviral response. Immunity 23(1):19-28 |
| abstractText | Toll-like receptors (TLRs) play an important role in antiviral response by recognizing viral components. Recently, a RNA helicase, RIG-I, was also suggested to recognize viral double-stranded RNA. However, how these molecules contribute to viral recognition in vivo is poorly understood. We show by gene targeting that RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs). RIG-I induces type I IFNs by activating IRF3 via IkappaB kinase-related kinases. In contrast, plasmacytoid DCs, which produce large amounts of IFN-alpha, use the TLR system rather than RIG-I for viral detection. Taken together, RIG-I and the TLR system exert antiviral responses in a cell type-specific manner. |
