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Publication : G protein Gi2 alpha in the cochlea: cloning and selective occurrence in receptor cells.

First Author  Tachibana M Year  1994
Journal  Brain Res Mol Brain Res Volume  21
Issue  3-4 Pages  355-8
PubMed ID  8170357 Mgi Jnum  J:16672
Mgi Id  MGI:64739 Doi  10.1016/0169-328x(94)90267-4
Citation  Tachibana M, et al. (1994) G protein Gi2 alpha in the cochlea: cloning and selective occurrence in receptor cells. Brain Res Mol Brain Res 21(3-4):355-8
abstractText  A cDNA library was made from the mouse cochlea and screened with a G protein-cDNA like molecule obtained from cochlear tissue by polymerase chain reaction. The nucleotide sequence of a clone, named cochlear Gi2 alpha, had 99.2% identity to mouse macrophage Gi2 alpha. Using an antibody which is selective for Gi2 alpha, expression of the cochlear Gi2 alpha was localized in outer and inner hair cells of the organ of Corti. Possible functional roles of this G protein in hair cells are discussed.
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