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Publication : Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain.

First Author  Li XY Year  1992
Journal  J Biol Chem Volume  267
Issue  13 Pages  8984-90
PubMed ID  1577736 Mgi Jnum  J:822
Mgi Id  MGI:49356 Doi  10.1016/s0021-9258(19)50377-5
Citation  Li XY, et al. (1992) Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain. J Biol Chem 267(13):8984-90
abstractText  NF-Y is a highly conserved transcription factor which recognizes CCAAT motifs in a variety of genes. We report here the genomic organization of the genes encoding both subunits, which gives interesting clues about the functional organization of the proteins. We also report the existence of isoforms of NF-YA which result from differential splicing. These alternative splicing events map within a glutamine-rich activation domain and show a marked cell- and tissue-specific bias.
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