| First Author | Haase VH | Year | 1991 |
| Journal | Oncogene | Volume | 6 |
| Issue | 12 | Pages | 2319-25 |
| PubMed ID | 1662793 | Mgi Jnum | J:1870 |
| Mgi Id | MGI:50394 | Citation | Haase VH, et al. (1991) Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain. Oncogene 6(12):2319-25 |
| abstractText | Ltk is a new member of the ros/insulin receptor family of tyrosine kinases that is expressed in murine B-lymphocyte precursors and forebrain neurons. We previously reported that lymphoid ltk cDNAs predict a 69 kDa transmembrane glycoprotein, which uses a CUG translational start codon and has a 110 amino acid putative extracellular domain. We now show that the predominant ltk mRNA in brain is alternatively spliced and predicts a protein with a substantially larger extracellular part. The human ltk gene maps to chromosome 15, bands q13-21, a region containing the breakpoint of a recurring chromosomal abnormality in B-cell non-Hodgkin lymphomas. |
