| First Author | Köhler M | Year | 1994 |
| Journal | J Biol Chem | Volume | 269 |
| Issue | 26 | Pages | 17367-70 |
| PubMed ID | 7545935 | Mgi Jnum | J:30462 |
| Mgi Id | MGI:77972 | Doi | 10.1016/s0021-9258(17)32444-4 |
| Citation | Kohler M, et al. (1994) The organization of the gene for the functionally dominant alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluR-B. J Biol Chem 269(26):17367-70 |
| abstractText | The murine gene encoding the GluR-B subunit of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors was characterized with respect to exon-intron organization, transcriptional start site, alternatively spliced transcripts, and adenosine to guanosine substitutions between gene and complementary DNA sequence. The GluR-B gene spans > 90 kilobase pairs and harbors 17 exons. Transcription appears to initiate approximately 430 nucleotides upstream of the translational start codon, with no intron in the 5'-untranslated region of the gene. Four alternatively spliced mRNAs are generated from the primary GluR-B transcript, two containing the modules Flip and Flop, and another two with alternate C-terminal coding sequence. The major GluR-B mRNAs in murine brain, 4 and 6 kilobase differ in the length of their 3'-untranslated region. |
