| First Author | Nishimura H | Year | 2001 |
| Journal | Science | Volume | 291 |
| Issue | 5502 | Pages | 319-22 |
| PubMed ID | 11209085 | Mgi Jnum | J:66979 |
| Mgi Id | MGI:1929567 | Doi | 10.1126/science.291.5502.319 |
| Citation | Nishimura H, et al. (2001) Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291(5502):319-22 |
| abstractText | Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology. Disruption of the gene encoding the negative immunoregulatory receptor PD-1 in BALB/c mice, but not in BALB/c RAG-2-/- mice, caused dilated cardiomyopathy with severely impaired contraction and sudden death by congestive heart failure. Affected hearts showed diffuse deposition of immunoglobulin G (IgG) on the surface of cardiomyocytes. All of the affected PD-1-/- mice exhibited high-titer circulating IgG autoantibodies reactive to a 33-kilodalton protein expressed specifically on the surface of cardiomyocytes. These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases. |
