| First Author | Workman CJ | Year | 2002 |
| Journal | J Immunol | Volume | 169 |
| Issue | 10 | Pages | 5392-5 |
| PubMed ID | 12421911 | Mgi Jnum | J:80063 |
| Mgi Id | MGI:2429474 | Doi | 10.4049/jimmunol.169.10.5392 |
| Citation | Workman CJ, et al. (2002) Cutting edge: Molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J Immunol 169(10):5392-5 |
| abstractText | Lymphocyte activation gene (LAG)-3 (CD223) is a CD4-related activation-induced cell surface molecule that binds to MHC class II molecules with high affinity and negatively regulates T cell expansion and homeostasis. In this study, we show that LAG-3 inhibits CD4-dependent, but not CD4-independent, T cell function via its cytoplasmic domain. Although high affinity interaction with MHC class II molecules is essential for LAG-3 function, tailless LAG-3 does not compete with CD4 for ligand binding. A single lysine residue (K468) within a conserved 'KIEELE' motif is essential for interaction with downstream signaling molecules. These data provide insight into the mechanism of action of this important T cell regulatory molecule. |
