| First Author | Yamaguchi K | Year | 1995 |
| Journal | Science | Volume | 270 |
| Issue | 5244 | Pages | 2008-11 |
| PubMed ID | 8533096 | Mgi Jnum | J:47270 |
| Mgi Id | MGI:1203659 | Doi | 10.1126/science.270.5244.2008 |
| Citation | Yamaguchi K, et al. (1995) Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270(5244):2008-11 |
| abstractText | The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was shown to participate in regulation of transcription by transforming growth factor-beta (TGF-beta). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-beta superfamily members. |
