| First Author | Ye B | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 23 | Pages | 4403-10 |
| PubMed ID | 17761173 | Mgi Jnum | J:126838 |
| Mgi Id | MGI:3762086 | Doi | 10.1016/j.febslet.2007.08.008 |
| Citation | Ye B, et al. (2007) GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway. FEBS Lett 581(23):4403-10 |
| abstractText | GRASP-1 is a neuronally enriched protein that interacts with the AMPA-type glutamate receptor/GRIP complex. GRASP-1 can be cleaved by Caspase-3 in both normal and ischemic brains although the functional significance of this cleavage remains elusive. We investigated signal transduction pathways that might lie downstream of GRASP-1 and found that GRASP-1 potently activates JNK pathway signaling, with no effect on ERK signaling. Such JNK pathway activating activity requires binding of GRASP-1 to both JNK and the upstream JNK pathway activator MEKK-1. Furthermore, mutations that prevent Caspase 3-cleavage of GRASP-1 dramatically inhibit the JNK pathway activating activity of GRASP-1, suggesting a novel link between Caspase-3 activation and JNK pathway signaling. These results suggest that GRASP-1 serves as a scaffold protein to facilitate MEKK-1 activation of JNK signaling in neurons. |
