| First Author | Baehr W | Year | 1991 |
| Journal | FEBS Lett | Volume | 278 |
| Issue | 1 | Pages | 107-14 |
| PubMed ID | 1847109 | Mgi Jnum | J:10983 |
| Mgi Id | MGI:59425 | Doi | 10.1016/0014-5793(91)80095-k |
| Citation | Baehr W, et al. (1991) Complete cDNA sequences of mouse rod photoreceptor cGMP phosphodiesterase alpha- and beta-subunits, and identification of beta'-, a putative beta-subunit isozyme produced by alternative splicing of the beta-subunit gene. FEBS Lett 278(1):107-14 |
| abstractText | We have characterized overlapping cDNA clones encoding cGMP phosphodiesterase (PDE) alpha- and beta-subunits of mouse retinal rod photoreceptors. The open reading frames predict an alpha-subunit of 100 kDa (856 residues), and a beta-subunit of 99 kDa (853 residues). Sequence analysis of two of twelve beta-subunit clones predicts the presence in the retina of an additional PDE, termed beta', which is generated by alternative splicing of the beta-subunit gene. beta' differs from beta only at the C-terminus being 55 residues shorter and lacking the Caax motif found at the C-termini of both the alpha- and beta-subunits. A 300 residue segment thought to contain the active site is present in the C-terminal half of alpha, beta and beta'. |
