| First Author | Goldsborough AS | Year | 1993 |
| Journal | Nucleic Acids Res | Volume | 21 |
| Issue | 1 | Pages | 127-34 |
| PubMed ID | 8441607 | Mgi Jnum | J:4013 |
| Mgi Id | MGI:52517 | Doi | 10.1093/nar/21.1.127 |
| Citation | Goldsborough AS, et al. (1993) Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11. Nucleic Acids Res 21(1):127-34 |
| abstractText | POU domain genes encode a family of highly conserved transacting factors that influence the transcriptional activity of several cell type-specific and ubiquitous genes. We have cloned and sequenced cDNAs encoding a novel mouse POU domain protein, Oct-11, that is closely related within the POU domain to the POU class II proteins, Oct-1 and Oct-2. Recombinant Oct-11 protein binds specifically to an octamer sequence in vitro. The Oct-11 gene is expressed during mouse embryogenesis and in the adult thymus and testis. In addition, it is abundant in the myeloma cell line P3/NS-1/1-Ag4.1. We describe the structure of Oct-11 and its chromosomal localization, and discuss the evidence that the POU class II gene family has evolved by duplication and divergence of a common ancestral gene. |
