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Publication : Molecular cloning of the complementary DNA for the mouse pyruvate kinase M-2 gene whose expression is dependent upon cell differentiation.

First Author  Izumi S Year  1995
Journal  Biochim Biophys Acta Volume  1267
Issue  2-3 Pages  135-8
PubMed ID  7612666 Mgi Jnum  J:26187
Mgi Id  MGI:73852 Doi  10.1016/0167-4889(95)00071-y
Citation  Izumi S, et al. (1995) Molecular cloning of the complementary DNA for the mouse pyruvate kinase M-2 gene whose expression is dependent upon cell differentiation. Biochim Biophys Acta 1267(2-3):135-8
abstractText  A cDNA encoding M2-type pyruvate kinase from mouse was cloned and its nucleotide sequence was determined. The cDNA encoded a protein containing 531 amino acids, the nucleotide and amino acid sequences of which were 93.2% and 98.1%, respectively, homologous to those of rat M2 pyruvate kinase. Expression of the pyruvate kinase in mouse embryonal carcinoma P19 cells altered according to differentiation stages; high at undifferentiated and low at differentiated stages.
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