| First Author | Wang X | Year | 2003 |
| Journal | Cell Death Differ | Volume | 10 |
| Issue | 5 | Pages | 580-91 |
| PubMed ID | 12728256 | Mgi Jnum | J:84999 |
| Mgi Id | MGI:2671972 | Doi | 10.1038/sj.cdd.4401208 |
| Citation | Wang X, et al. (2003) NRADD, a novel membrane protein with a death domain involved in mediating apoptosis in response to ER stress. Cell Death Differ 10(5):580-91 |
| abstractText | NRADD (neurotrophin receptor alike death domain protein) is a novel protein with transmembrane and cytoplasmic regions highly homologous to death receptors, particularly p75(NTR). However, the short N-terminal domain is unique. Expression of NRADD induced apoptosis in a number of cell lines. The apoptotic mechanism involved the activation of caspase-8 and execution of apoptosis without requiring mitochondrial components. The activation of this death receptor-like mechanism required the N-terminal domain, which is N-glycosylated and needed for subcellular targeting. Deletion of the N-terminal domain produced a dominant-negative form of NRADD that protected neurons and Schwann cells from a variety of endoplasmic reticulum (ER) stressors. NRADD may therefore be a necessary component for generating an ER-induced proapoptotic signal.Cell Death and Differentiation (2003) 10, 580-591. doi:10.1038/sj.cdd.4401208 |
