| First Author | Wei CC | Year | 2003 |
| Journal | Genes Immun | Volume | 4 |
| Issue | 3 | Pages | 204-11 |
| PubMed ID | 12700595 | Mgi Jnum | J:83521 |
| Mgi Id | MGI:2662350 | Doi | 10.1038/sj.gene.6363947 |
| Citation | Wei CC, et al. (2003) Cloning and characterization of mouse IL-22 binding protein. Genes Immun 4(3):204-11 |
| abstractText | Interleukin-22 (IL-22), a member of IL-10 family, plays some important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered, a membrane-bound receptor and a soluble receptor, both encoded by different genes. IL-22 may be involved in inflammatory processes specifically regulated by soluble receptors. By screening a mouse genomic library for a human IL-22 binding protein homologue, we identified the mouse genomic clone of IL-22 binding protein. Its coding sequence was verified and isolated by RT-PCR. The gene encodes a protein of 230 amino acids that share 67.1% amino-acid sequence identity with human IL-22 binding protein. We designated this receptor 'mouse IL-22 binding protein' (mIL-22BP). mIL-22BP could be upregulated by LPS stimulation in mouse monocytes. mIL-22BP binds to mouse and human IL-22 and neutralizes STAT3 activation induced by both cytokines in human and rat hepatoma cell lines. Treating B cells with mouse IL-22 induces production of reactive oxygen species, which mIL-22BP blocks.Genes and Immunity (2003) 4, 204-211. doi:10.1038/sj.gene.6363947 |
