First Author | Haire MF | Year | 1996 |
Journal | Brain Res Mol Brain Res | Volume | 36 |
Issue | 1 | Pages | 174-8 |
PubMed ID | 9011755 | Mgi Jnum | J:31447 |
Mgi Id | MGI:78955 | Doi | 10.1016/0169-328x(95)00282-w |
Citation | Haire MF, et al. (1996) Transient expression of the basic helix-loop-helix protein NSCL-2 in the mouse cerebellum during postnatal development. Brain Res Mol Brain Res 36(1):174-8 |
abstractText | The spatio-temporal expression of the basic helix-loop-helix transcription factor NSCL-2 was analyzed in the postnatal development of the murine brain by in situ hybridization. We found that NSCL-2 is transiently expressed in the cerebellum. NSCL-2 was found exclusively in the premigratory zone of the external granule layer where postmitotic neurons undergo initial stages of neuronal differentiation. NSCL-2 expression was not detected in mature neurons. This pattern of expression suggests that NSCL-2 is critical for the onset of neuronal differentiation, but not for the maintenance of the differentiated state. |