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Publication : Transient expression of the basic helix-loop-helix protein NSCL-2 in the mouse cerebellum during postnatal development.

First Author  Haire MF Year  1996
Journal  Brain Res Mol Brain Res Volume  36
Issue  1 Pages  174-8
PubMed ID  9011755 Mgi Jnum  J:31447
Mgi Id  MGI:78955 Doi  10.1016/0169-328x(95)00282-w
Citation  Haire MF, et al. (1996) Transient expression of the basic helix-loop-helix protein NSCL-2 in the mouse cerebellum during postnatal development. Brain Res Mol Brain Res 36(1):174-8
abstractText  The spatio-temporal expression of the basic helix-loop-helix transcription factor NSCL-2 was analyzed in the postnatal development of the murine brain by in situ hybridization. We found that NSCL-2 is transiently expressed in the cerebellum. NSCL-2 was found exclusively in the premigratory zone of the external granule layer where postmitotic neurons undergo initial stages of neuronal differentiation. NSCL-2 expression was not detected in mature neurons. This pattern of expression suggests that NSCL-2 is critical for the onset of neuronal differentiation, but not for the maintenance of the differentiated state.
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