| First Author | Lin Q | Year | 1997 |
| Journal | Science | Volume | 276 |
| Issue | 5317 | Pages | 1404-7 |
| PubMed ID | 9162005 | Mgi Jnum | J:40724 |
| Mgi Id | MGI:892058 | Doi | 10.1126/science.276.5317.1404 |
| Citation | Lin Q, et al. (1997) Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276(5317):1404-7 |
| abstractText | Members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)-box transcription factors bind an A-T-rich DNA sequence associated with muscle-specific genes. The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube. In mice homozygous for a null mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right ventricle did not form, and a subset of cardiac muscle genes was not expressed. The absence of the right ventricular region of the mutant heart correlated with down-regulation of the dHAND gene, which encodes a basic helix-loop-helix transcription factor required for cardiac morphogenesis. Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development. |
