| First Author | Khakh BS | Year | 2003 |
| Journal | J Neurosci | Volume | 23 |
| Issue | 19 | Pages | 7426-37 |
| PubMed ID | 12917379 | Mgi Jnum | J:88199 |
| Mgi Id | MGI:3029660 | Doi | 10.1523/JNEUROSCI.23-19-07426.2003 |
| Citation | Khakh BS, et al. (2003) ATP modulation of excitatory synapses onto interneurons. J Neurosci 23(19):7426-37 |
| abstractText | Inhibitory interneurons play important roles in neuronal circuits, but the synaptic mechanisms that regulate excitatory input onto interneurons remain to be fully understood. We show that ATP-gated presynaptic P2X2 channels facilitate excitatory transmission onto stratum radiatum interneurons but not onto CA1 pyramidal neurons. ATP released endogenously during carbachol-induced oscillations facilitates excitatory synapses onto interneurons. Overall, these data provide evidence for the molecular identity, synaptic function, and interneuron synapse specificity of a presynaptic neurotransmitter-gated cation channel. The findings highlight a novel form of presynaptic facilitation for hippocampal interneurons and suggest a role for extracellular ATP in neuronal networks. |
