| First Author | Sasaki M | Year | 2006 |
| Journal | Science | Volume | 312 |
| Issue | 5773 | Pages | 589-92 |
| PubMed ID | 16556803 | Mgi Jnum | J:108335 |
| Mgi Id | MGI:3623706 | Doi | 10.1126/science.1122352 |
| Citation | Sasaki M, et al. (2006) A voltage sensor-domain protein is a voltage-gated proton channel. Science 312(5773):589-92 |
| abstractText | Voltage-gated proton channels have been widely observed but have not been identified at a molecular level. Here we report that a four-transmembrane protein similar to the voltage-sensor domain of voltage-gated ion channels is a voltage-gated proton channel. Cells overexpressing this protein showed depolarization-induced outward currents accompanied by tail currents. Current reversal occured at equilibrium potentials for protons. The currents exhibited pH-dependent gating and zinc ion sensitivity, two features which are characteristic of voltage-gated proton channels. Responses of voltage dependence to sequence changes suggest that mouse voltage-sensor domain-only protein is itself a channel, rather than a regulator of another channel protein. |
