| First Author | Pflugh DL | Year | 2000 |
| Journal | J Immunol | Volume | 165 |
| Issue | 1 | Pages | 313-21 |
| PubMed ID | 10861067 | Mgi Jnum | J:62857 |
| Mgi Id | MGI:1859985 | Doi | 10.4049/jimmunol.165.1.313 |
| Citation | Pflugh DL, et al. (2000) Ly-6I, a new member of the murine Ly-6 superfamily with a distinct pattern of expression. J Immunol 165(1):313-21 |
| abstractText | A new member of the mouse Ly-6SF, designated Ly-6I, has been isolated as a gene homologous to a segment of the Ly-6C gene. A single allelic difference in the mature protein sequence was identified, which is similar to other Ly-6SF members. Ly-6I mRNA has been detected in a wide range of tissues and cell lines, and a rabbit polyclonal Ab has been used to determine that Ly-6I protein is present at a low constitutive level on cell lines from several different lineages. In contrast to Ly-6C and Ly-6A/E, the Ly-6I gene is only weakly responsive to IFNs. Expression in vivo is most abundant on bone marrow populations and is coexpressed with Ly-6C on granulocytes and macrophages. However, Ly-6I is also expressed on immature B cell populations that do not express Ly-6C. Expression on mature B cells in spleen is uniformly low. Similarly, Ly-6I is expressed on TCRlow/int, but not TCRhigh, thymocytes. Ly-6I is re-expressed on Ly-6Chigh T cells in the periphery. Thus, Ly-6I may be a useful marker to define maturation stages of both T and B lymphocytes as well as subsets of monocytes and granulocytes. |
