| First Author | Xiao G | Year | 2001 |
| Journal | Mol Cell | Volume | 7 |
| Issue | 2 | Pages | 401-9 |
| PubMed ID | 11239468 | Mgi Jnum | J:67738 |
| Mgi Id | MGI:1931349 | Doi | 10.1016/s1097-2765(01)00187-3 |
| Citation | Xiao G, et al. (2001) NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 7(2):401-9 |
| abstractText | Processing of the nf(kappa)b2 gene product p100 to generate p52 is an important step in NF-kappaB regulation. We show that this step is negatively regulated by a processing-inhibitory domain (PID) within p100 and positively regulated by the NF-kappaB-inducing kinase (NIK). While the PID suppresses the constitutive processing of p100, NIK induces p100 processing by stimulating site-specific phosphorylation and ubiquitination of this precursor protein. Further, a natural mutation of the gene encoding NIK in alymphoplasia (aly) mice cripples the function of NIK in p100 processing, causing a severe defect in p52 production. These data suggest that NIK is a specific kinase regulating p100 processing and explain why the aly and nf(kappa)b2 knockout mice exhibit similar immune deficiencies. |
