| First Author | Yamamoto K | Year | 2016 |
| Journal | J Biol Chem | Volume | 291 |
| Issue | 30 | Pages | 15602-13 |
| PubMed ID | 27226633 | Mgi Jnum | J:235447 |
| Mgi Id | MGI:5796418 | Doi | 10.1074/jbc.M116.734657 |
| Citation | Yamamoto K, et al. (2016) Expression and Function of Group IIE Phospholipase A2 in Mouse Skin. J Biol Chem 291(30):15602-13 |
| abstractText | Recent studies using knock-out mice for various secreted phospholipase A2 (sPLA2) isoforms have revealed their non-redundant roles in diverse biological events. In the skin, group IIF sPLA2 (sPLA2-IIF), an "epidermal sPLA2" expressed in the suprabasal keratinocytes, plays a fundamental role in epidermal-hyperplasic diseases such as psoriasis and skin cancer. In this study, we found that group IIE sPLA2 (sPLA2-IIE) was expressed abundantly in hair follicles and to a lesser extent in basal epidermal keratinocytes in mouse skin. Mice lacking sPLA2-IIE exhibited skin abnormalities distinct from those in mice lacking sPLA2-IIF, with perturbation of hair follicle ultrastructure, modest changes in the steady-state expression of a subset of skin genes, and no changes in the features of psoriasis or contact dermatitis. Lipidomics analysis revealed that sPLA2-IIE and -IIF were coupled with distinct lipid pathways in the skin. Overall, two skin sPLA2s, hair follicular sPLA2-IIE and epidermal sPLA2-IIF, play non-redundant roles in distinct compartments of mouse skin, underscoring the functional diversity of multiple sPLA2s in the coordinated regulation of skin homeostasis and diseases. |
