| First Author | Applebury ML | Year | 2000 |
| Journal | Neuron | Volume | 27 |
| Issue | 3 | Pages | 513-23 |
| PubMed ID | 11055434 | Mgi Jnum | J:64746 |
| Mgi Id | MGI:1889936 | Doi | 10.1016/s0896-6273(00)00062-3 |
| Citation | Applebury ML, et al. (2000) The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning. Neuron 27(3):513-23 |
| abstractText | Mice express S and M opsins that form visual pigments for the detection of light and visual signaling in cones. Here, we show that S opsin transcription is higher than that of M opsin, which supports ultraviolet (UV) sensitivity greater than midwavelength sensitivity. Surprisingly, most cones coexpress both S and M opsins in a common cone cell type throughout the retina. All cones express M opsin, but the levels are graded from dorsal to ventral. The levels of S opsin are relatively constant. However, in the far dorsal retina, S opsin is repressed stochastically, such that some cones express M opsin only. These observations indicate that two different mechanisms control M and S opsin expression. We suggest that a common cone type is patterned across the retinal surface to produce phenotypic cone subtypes. |
