| First Author | Lee HK | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 9 | Pages | 2253-7 |
| PubMed ID | 16574105 | Mgi Jnum | J:180473 |
| Mgi Id | MGI:5306307 | Doi | 10.1016/j.febslet.2006.03.033 |
| Citation | Lee HK, et al. (2006) Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo. FEBS Lett 580(9):2253-7 |
| abstractText | Tumor endothelial marker 7 (TEM7) is a novel transmembrane protein that is highly expressed in the tumor endothelium. However, the ligands and functions of TEM7 are unknown at present. Using a recombinant ectodomain of TEM7 as a probe, we could identify the saturable interaction between nidogen and TEM7 in vitro. A cell overlay binding assay showed that recombinant nidogen interact with full length TEM7 on cell surface. Finally, nidogen/TEM7 interaction enhanced cell spreading in TEM7 transfected 293T cells. This novel nidogen/TEM7 interaction may provide an important molecular tool with potential therapeutic applications in the anti-angiogenic therapies. |
