| First Author | Mulac-Jericevic B | Year | 2000 |
| Journal | Science | Volume | 289 |
| Issue | 5485 | Pages | 1751-4 |
| PubMed ID | 10976068 | Mgi Jnum | J:77661 |
| Mgi Id | MGI:2182227 | Doi | 10.1126/science.289.5485.1751 |
| Citation | Mulac-Jericevic B, et al. (2000) Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science 289(5485):1751-4 |
| abstractText | Progesterone regulates reproductive function through two intracellular receptors, progesterone receptor-A (PR-A) and progesterone receptor-B (PR-B), that arise from a single gene and function as transcriptional regulators of progesterone-responsive genes. Although in vitro studies show that PR isoforms can display different transcriptional regulatory activities, their physiological significance is unknown. By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset of reproductive functions of progesterone by regulation of a subset of progesterone-responsive target genes. Thus, PR-A and PR-B are functionally distinct mediators of progesterone action in vivo and should provide suitable targets for generation of tissue-selective progestins. |
