| First Author | Manning CE | Year | 2019 |
| Journal | Neuroscience | Volume | 406 |
| Pages | 225-233 | PubMed ID | 30902680 |
| Mgi Jnum | J:276166 | Mgi Id | MGI:6313976 |
| Doi | 10.1016/j.neuroscience.2019.03.022 | Citation | Manning CE, et al. (2019) Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning. Neuroscience 406:225-233 |
| abstractText | Neural proliferation in the dentate gyrus (DG) is closely linked with learning and memory, but the transcriptional programming that drives adult proliferation remains incompletely understood. Our lab previously elucidated the critical role of the transcription factor DeltaFosB in the dorsal hippocampus (dHPC) in learning and memory, and the FosB gene has been suggested to play a role in neuronal proliferation. However, the subregion-specific and potentially cell-autonomous role of dHPC DeltaFosB in neurogenesis-dependent learning has not been studied. Here, we crossed neurotensin receptor-2 (NtsR2) Cre mice, which express Cre within the subgranular zone (SGZ) of dHPC DG, with floxed FosB mice to show that knockout of DeltaFosB in hippocampal SGZ neurons reduces antidepressant-induced neurogenesis and impedes hippocampus-dependent learning in the novel object recognition task. Taken together, these data indicate that FosB gene expression in SGZ is necessary for both hippocampal neurogenesis and memory formation. |
