| First Author | Fischer H | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 281 |
| Issue | 3 | Pages | 795-803 |
| PubMed ID | 11237729 | Mgi Jnum | J:74707 |
| Mgi Id | MGI:2158991 | Doi | 10.1006/bbrc.2001.4345 |
| Citation | Fischer H, et al. (2001) C7, a novel nucleolar protein, is the mouse homologue of the Drosophila late puff product L82 and an isoform of human OXR1. Biochem Biophys Res Commun 281(3):795-803 |
| abstractText | The C7 gene was identified in a project aimed to characterize differential gene expression upon attachment of cells to extracellular matrix proteins in vitro. C7 is the homologue of Drosophila L82, a late puff gene (Stowers et al. (1999) Dev. Biol. 213, 116-130) and human OXR1, a gene, which protects cells against oxidation (Volkert et al. (2000) Proc. Natl. Acad. Sci. USA 97, 14530-14535). All are transcribed into multiple splice forms with a common 3' domain. Additional members of this novel gene family are found in a number of eukaryotic species. In the mouse, the C7 gene is highly and broadly expressed during development in at least 4 splice forms, 3 of which were sequenced. In the adult, the C7 gene is most highly expressed in brain and testis. Antibodies to recombinant C7 protein localized to nucleoli in a variety of cell types, suggesting that C7 may be involved in the formation or function of this important organelle. |
