| First Author | Reim K | Year | 2001 |
| Journal | Cell | Volume | 104 |
| Issue | 1 | Pages | 71-81 |
| PubMed ID | 11163241 | Mgi Jnum | J:86365 |
| Mgi Id | MGI:2679622 | Doi | 10.1016/s0092-8674(01)00192-1 |
| Citation | Reim K, et al. (2001) Complexins regulate a late step in Ca2+-dependent neurotransmitter release. Cell 104(1):71-81 |
| abstractText | Synaptic vesicle fusion at synapses is triggered by increases in cytosolic Ca2+ levels. However, the identity of the Ca2+ sensor and the transduction mechanism of the Ca2+ trigger are unknown. We show that Complexins, stoichiometric components of the exocytotic core complex, are important regulators of transmitter release at a step immediately preceding vesicle fusion. Neurons lacking Complexins show a dramatically reduced transmitter release efficiency due to decreased Ca2+ sensitivity of the synaptic secretion process. Analyses of mutant neurons demonstrate that Complexins are acting at or following the Ca2+-triggering step of fast synchronous transmitter release by regulating the exocytotic Ca2+ sensor, its interaction with the core complex fusion machinery, or the efficiency of the fusion apparatus itself. |
