| First Author | Calligaris R | Year | 1995 |
| Journal | Proc Natl Acad Sci U S A | Volume | 92 |
| Issue | 25 | Pages | 11598-602 |
| PubMed ID | 8524811 | Mgi Jnum | J:30154 |
| Mgi Id | MGI:77668 | Doi | 10.1073/pnas.92.25.11598 |
| Citation | Calligaris R, et al. (1995) Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor. Proc Natl Acad Sci U S A 92(25):11598-602 |
| abstractText | GATA-1 is a zinc-finger transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. In human and murine erythroid cells a previously undescribed 40-kDa protein is detected with GATA-1-specific antibodies. We show that the 40-kDa GATA-1 (GATA-1s) is produced by the use of an internal AUG initiation codon in the GATA-1 transcript. The GATA-1 proteins share identical binding activity and form heterodimers in erythroleukemic cells but differ in their transactivation potential and in their expression in developing mouse embryos. |
