| First Author | Chavrier P | Year | 1988 |
| Journal | EMBO J | Volume | 7 |
| Issue | 1 | Pages | 29-35 |
| PubMed ID | 3129290 | Mgi Jnum | J:9144 |
| Mgi Id | MGI:57607 | Doi | 10.1002/j.1460-2075.1988.tb02780.x |
| Citation | Chavrier P, et al. (1988) A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J 7(1):29-35 |
| abstractText | Zinc fingers are DNA-binding domains present in several eukaryotic regulatory proteins. We have identified a mouse gene, Krox-20, encoding a protein with three zinc fingers and whose expression is activated during G0/G1 transition in cultured cells. Serum stimulation of quiescent cells leads to rapid and transient accumulation of Krox-20 mRNA, with kinetics similar to those of the c-fos proto-oncogene. The induction does not require de-novo protein synthesis. In the mouse, Krox-20 is expressed at low levels in tissues which contain rapidly dividing cells. These properties suggest that Krox-20 encodes a transcription control factor, possibly involved in the modulation of cell proliferation. |
