| First Author | Yanagisawa K | Year | 1993 |
| Journal | FEBS Lett | Volume | 318 |
| Issue | 1 | Pages | 83-7 |
| PubMed ID | 7916701 | Mgi Jnum | J:17554 |
| Mgi Id | MGI:65590 | Doi | 10.1016/0014-5793(93)81333-u |
| Citation | Yanagisawa K, et al. (1993) Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1. FEBS Lett 318(1):83-7 |
| abstractText | In the course of studying the ST2 gene, which was initially found to be expressed specifically at the G0/G1 transitional state in BALB/c-3T3 cells and was one of the primary response genes, we found another ST2-related mRNA, designated as ST2L, in serum-stimulated BALB/c-3T3 cells in the presence of cycloheximide. Nucleotide sequence analysis of the cloned ST2L cDNA revealed that it had an open reading frame encoding a polypeptide of 567 amino acids. A 5' region (1,028 nucleotides) of ST2L cDNA was identical with the ST2 cDNA, and a unique 3' region encoded a putative transmembrane domain of 24 amino acids and a cytoplasmic domain of 201 amino acids. The ST2 gene product is highly similar to the extracellular portion of IL-1 receptors type 1 and type 2, and the ST2L gene product shows a marked similarity with entire IL-1 receptor type 1. |
