| First Author | Ichii H | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 6 | Pages | 558-63 |
| PubMed ID | 12021781 | Mgi Jnum | J:76771 |
| Mgi Id | MGI:2180259 | Doi | 10.1038/ni802 |
| Citation | Ichii H, et al. (2002) Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells. Nat Immunol 3(6):558-63 |
| abstractText | Naive T cells proliferate and differentiate into memory cells after antigenic stimulation or in a lymphopenic environment. We showed here transient increases in memory phenotype CD8+ T cell numbers in the lymphopenic environment of spleens of very young mice. The magnitude of the increase correlated with Bcl-6 expression in the T cells. Bcl-6 controlled the generation and maintenance of antigen-specific memory phenotype CD8+ T cells in the spleens of immunized mice. These data suggest that Bcl-6, which is essential for memory B cell development in germinal centers, is a key molecule for the establishment not only of memory T cells but also of the peripheral T cell compartment in infancy. |
