| First Author | Hammond KL | Year | 1998 |
| Journal | Mech Dev | Volume | 74 |
| Issue | 1-2 | Pages | 121-31 |
| PubMed ID | 9651501 | Mgi Jnum | J:49282 |
| Mgi Id | MGI:1277071 | Doi | 10.1016/s0925-4773(98)00071-9 |
| Citation | Hammond KL, et al. (1998) Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb. Mech Dev 74(1-2):121-31 |
| abstractText | We have isolated mammalian homologues of the Drosophila dachshund gene. Two domains of high conservation, one of which contains an alpha-helical, coiled-coil motif, show similarity to the Ski family of genes. We therefore propose that Dachshund belongs to a superfamily including these genes. Mouse Dachshund (Dach) is expressed in the eye and limb, structures affected by the Drosophila loss-of-function mutant, and rib primordia, CNS and genital eminence. Pax6 and Dach show overlapping but non-identical expression patterns. Dach expression is unaffected in smalleye mouse brain, indicating that Pax6 is not directly activating Dach. In Drosophila eye development dachshund is a component of an interacting network of proteins. Genes homologous to many of these exist in mammals; Dach joins this expanding group. Copyright 1998 Elsevier Science Ireland Ltd. All rights reserved |
