| First Author | Weisberg E | Year | 1998 |
| Journal | Mech Dev | Volume | 79 |
| Issue | 1-2 | Pages | 17-27 |
| PubMed ID | 10349617 | Mgi Jnum | J:52223 |
| Mgi Id | MGI:1328655 | Doi | 10.1016/s0925-4773(98)00160-9 |
| Citation | Weisberg E, et al. (1998) A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. Mech Dev 79(1-2):17-27 |
| abstractText | The transcription factor FAST-1 has recently been shown to play a key role in the specification of mesoderm by TGF beta superfamily signals in the early Xenopus embryo. We have cloned Fast1, a mouse homologue of Xenopus FAST-1, and characterized its expression during embryogenesis and function in activin/TGF beta signal transduction. In vitro, Fast1 associates with Smads in response to an activin/TGF beta signal to form a complex that recognizes the Xenopus activin responsive element (ARE) targeted by Xenopus FAST-1. In intact cells, introduction of Fast1 confers activin/TGF beta regulation of an ARE-luciferase reporter. In embryos, Fast1 is expressed predominantly throughout the epiblast before gastrulation and declines as development progresses. We propose that mouse Fast1, like Xenopus FAST-1, mediates TGF beta superfamily signals specifying developmental fate during early embryogenesis. |
