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Publication : A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction.

First Author  Wilson-Shaw D Year  1991
Journal  FEBS Lett Volume  284
Issue  2 Pages  211-5
PubMed ID  1647983 Mgi Jnum  J:14374
Mgi Id  MGI:62544 Doi  10.1016/0014-5793(91)80687-x
Citation  Wilson-Shaw D, et al. (1991) A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction. FEBS Lett 284(2):211-5
abstractText  We have utilized a polymerase chain reaction (PCR) strategy to identify a novel subunit, gamma 3, of the GABAA receptor. The gamma 3 cDNA encodes a mature protein of 450 amino acids that contains structural features typically conserved among subunits of the GABAA receptor family. The gamma 3 subunit shares approximately 66% sequence identity with the gamma 2 subunit but only 38% and 29% with alpha 1 and beta 1 subunits, respectively. Localization of the gamma 3 mRNA indicates that it is widely distributed throughout the mouse brain in a pattern similar to that observed for mRNAs encoding the gamma 2 subunits.
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