First Author | Wilson-Shaw D | Year | 1991 |
Journal | FEBS Lett | Volume | 284 |
Issue | 2 | Pages | 211-5 |
PubMed ID | 1647983 | Mgi Jnum | J:14374 |
Mgi Id | MGI:62544 | Doi | 10.1016/0014-5793(91)80687-x |
Citation | Wilson-Shaw D, et al. (1991) A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction. FEBS Lett 284(2):211-5 |
abstractText | We have utilized a polymerase chain reaction (PCR) strategy to identify a novel subunit, gamma 3, of the GABAA receptor. The gamma 3 cDNA encodes a mature protein of 450 amino acids that contains structural features typically conserved among subunits of the GABAA receptor family. The gamma 3 subunit shares approximately 66% sequence identity with the gamma 2 subunit but only 38% and 29% with alpha 1 and beta 1 subunits, respectively. Localization of the gamma 3 mRNA indicates that it is widely distributed throughout the mouse brain in a pattern similar to that observed for mRNAs encoding the gamma 2 subunits. |