| First Author | Shapiro L | Year | 1995 |
| Journal | Nature | Volume | 374 |
| Issue | 6520 | Pages | 327-37 |
| PubMed ID | 7885471 | Mgi Jnum | J:23891 |
| Mgi Id | MGI:71628 | Doi | 10.1038/374327a0 |
| Citation | Shapiro L, et al. (1995) Structural basis of cell-cell adhesion by cadherins [see comments]. Nature 374(6520):327-37 |
| abstractText | Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells. |
