| First Author | Harada H | Year | 1989 |
| Journal | Cell | Volume | 58 |
| Issue | 4 | Pages | 729-39 |
| PubMed ID | 2475256 | Mgi Jnum | J:17557 |
| Mgi Id | MGI:65593 | Doi | 10.1016/0092-8674(89)90107-4 |
| Citation | Harada H, et al. (1989) Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 58(4):729-39 |
| abstractText | Viral infections commonly induce expression of type I interferon (IFN) genes. The induction is transient and involves transcriptional activation wherein a positive factor, IRF-1, binds to upstream regulatory cis elements. In the present study we report the isolation of a cDNA encoding a novel factor, termed IRF-2, that interacts with the same nucleotide sequence elements as IRF-1. Both genes are inducible not only by virus but also by IFN. Unlike IRF-1, IRF-2 does not function as an activator; rather, it suppresses the function of IRF-1 under certain circumstances. Our results suggest that transcription of the IFN and IFN-inducible genes is regulated by two similar trans-acting factors that apparently compete for the same cis-acting recognition sequences, but which have opposite effects. |
