| First Author | Hyka-Nouspikel N | Year | 2006 |
| Journal | Immunol Rev | Volume | 214 |
| Pages | 106-17 | PubMed ID | 17100879 |
| Mgi Jnum | J:148086 | Mgi Id | MGI:3843504 |
| Doi | 10.1111/j.1600-065X.2006.00456.x | Citation | Hyka-Nouspikel N, et al. (2006) Physiological roles of murine DAP10 adapter protein in tumor immunity and autoimmunity. Immunol Rev 214:106-17 |
| abstractText | The immune system has evolved to tolerate what is self and reject what is foreign. The recognition of self from non-self is performed by activating and inhibitory receptors, which signal immune cells via adapter molecules, determining the outcome of the immune response. DAP10, a transmembrane adapter protein expressed broadly in hematopoietic cells, associates with NKG2D activating receptor forming a multisubunit complex, which recognizes self-proteins upregulated during tumorigenesis, infection, and autoimmune response. Analysis of immune reactions against syngeneic tumors, as well as autoimmune responses in the DAP10-deficient mice, revealed an important physiological role of DAP10 signaling in maintaining tolerance to self, probably by controlling the development and activation threshold of autoreactive T cells. |
