| First Author | Yang P | Year | 2017 |
| Journal | Science | Volume | 356 |
| Issue | 6339 | Pages | 757-759 |
| PubMed ID | 28522536 | Mgi Jnum | J:243423 |
| Mgi Id | MGI:5908476 | Doi | 10.1126/science.aah6895 |
| Citation | Yang P, et al. (2017) A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568. Science 356(6339):757-759 |
| abstractText | Insulin-like growth factor 2 (IGF2) is the major fetal growth hormone in mammals. We identify zinc finger protein 568 (ZFP568), a member of the rapidly evolving Kruppel-associated box-zinc finger protein (KRAB-ZFP) family linked primarily to silencing of endogenous retroelements, as a direct repressor of a placental-specific Igf2 transcript (designated Igf2-P0) in mice. Loss of Zfp568, which causes gastrulation failure, or mutation of the ZFP568-binding site at the Igf2-P0 promoter causes inappropriate Igf2-P0 activation. Deletion of Igf2 can completely rescue Zfp568 gastrulation phenotypes through late gestation. Our data highlight the exquisite selectivity with which members of the KRAB-ZFP family repress their targets and identify an additional layer of transcriptional control of a key growth factor regulating fetal and placental development. |
