| First Author | Beppu H | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 235 |
| Issue | 3 | Pages | 499-504 |
| PubMed ID | 9207184 | Mgi Jnum | J:41492 |
| Mgi Id | MGI:893970 | Doi | 10.1006/bbrc.1997.6816 |
| Citation | Beppu H, et al. (1997) cDNA cloning and genomic organization of the mouse BMP type II receptor. Biochem Biophys Res Commun 235(3):499-504 |
| abstractText | The cDNA for the mouse bone morphogenetic protein type II receptor (BMPR-II) was isolated using the human counterpart as a probe and its genomic structure was determined. The cDNA encodes a protein of 1,038 amino acids with a single transmembrane domain, a serine/threonine kinase domain, and a long carboxy-terminal tail. The overall amino acid sequence identity between the mouse and the human BMPR-II is 96.6%. mRNA is widely distributed in various adult tissues. The gene is encoded by 13 exons spanning over 80 kb. Two large introns (intron 1 and 3) contribute to the majority of the gene size, as in the mouse activin type II receptor gene. The intron/exon boundaries were sequenced. The results suggest that alternative splicing can yield a shorter form of BMPR-II of 530 amino acids, as reported previously. Knowledge of the structure of the BMPR-II gene is essential for the understanding of the role of bone morphogenetic proteins in the developmental and physiological processes of animals. |
