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Publication : Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation.

First Author  Svingen T Year  2007
Journal  Int J Dev Biol Volume  51
Issue  3 Pages  255-8
PubMed ID  17486547 Mgi Jnum  J:120357
Mgi Id  MGI:3706344 Doi  10.1387/ijdb.062219ts
Citation  Svingen T, et al. (2007) Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation. Int J Dev Biol 51:255-258
abstractText  Aard (alanine and arginine rich domain) is a gene of unknown function, previously reported to show sexually dimorphic expression in fetal mouse gonads. Here we describe the spatio-temporal expression profile of Aard during gonad development. The period of elevated mRNA expression coincides with early differentiation of the testis and is limited to Sertoli cells of the developing testis cords. Although low levels of Aard transcripts were detected in other tissues by quantitative RT-PCR assays, high levels of Aard expression is specific to the testis in both embryonic and adult mice.
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