| First Author | Milochau A | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 14 | Pages | 2217-22 |
| PubMed ID | 24882364 | Mgi Jnum | J:211330 |
| Mgi Id | MGI:5574516 | Doi | 10.1016/j.febslet.2014.05.031 |
| Citation | Milochau A, et al. (2014) Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. FEBS Lett 588(14):2217-22 |
| abstractText | Synaptotagmins are two C2 domain-containing transmembrane proteins. The function of calcium-sensitive members in the regulation of post-Golgi traffic has been well established whereas little is known about the calcium-insensitive isoforms constituting half of the protein family. Novel binding partners of synaptotagmin 11 were identified in beta-cells. A number of them had been assigned previously to ER/Golgi derived-vesicles or linked to RNA synthesis, translation and processing. Whereas the C2A domain interacted with the Q-SNARE Vti1a, the C2B domain of syt11 interacted with the SND1, Ago2 and FMRP, components of the RNA-induced silencing complex (RISC). Binding to SND was direct via its N-terminal tandem repeats. Our data indicate that syt11 may provide a link between gene regulation by microRNAs and membrane traffic. |
