| First Author | Maedera S | Year | 2019 |
| Journal | FEBS Lett | Volume | 593 |
| Issue | 2 | Pages | 195-208 |
| PubMed ID | 30431159 | Mgi Jnum | J:270487 |
| Mgi Id | MGI:6276413 | Doi | 10.1002/1873-3468.13298 |
| Citation | Maedera S, et al. (2019) GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages. FEBS Lett 593(2):195-208 |
| abstractText | The solute carrier family is an important protein class governing compound transport across membranes. However, some of its members remain functionally unidentified. We analyzed ChIP-seq data for the NF-kappaB family transcription factor RelA and identified GLUT6 as a functionally uncharacterized transporter that putatively works in inflammatory responses. Inflammatory stimuli increase GLUT6 expression level, although GLUT6-knockout mice exhibit a subtle phenotype to lipopolysaccharide administration. Metabolomics and in vitro analyses show that GLUT6 functions as a glycolysis modulator in inflammatory macrophages. GLUT6 does not mediate glucose uptake and is localized on lysosomal membranes. We conclude that GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates inflammatory responses by affecting the metabolic shift in macrophages. |
