| First Author | Ueda Y | Year | 1999 |
| Journal | Mamm Genome | Volume | 10 |
| Issue | 9 | Pages | 879-82 |
| PubMed ID | 10441738 | Mgi Jnum | J:56833 |
| Mgi Id | MGI:1342785 | Doi | 10.1007/s003359901107 |
| Citation | Ueda Y, et al. (1999) Nucleotide sequences of the mouse globin beta gene cDNAs in a wild derived new haplotype Hbb(w1). Mamm Genome 10(9):879-82 |
| abstractText | Haplotypes of the beta-globin gene complex (Hbb) in laboratory mice have been defined as d, p, and s. We previously found a new haplotype w1 in wild mice collected from northwestern China. This study analyzed the nucleotide sequences of b1 and b2-globin gene cDNAs of both the p and w1 haplotypes, in comparison with those of the d haplotype. In Hbb-b1 cDNA, six base substitutions were found between the d and w1 haplotypes and also between p and w1, but none existed between d and p. In Hbb-b2 cDNA, three base substitutions were found between the d and w1 haplotypes and also between d and p, but none between p and w1. This result indicated that the Hbb gene complex of the p haplotype carries b1(d) and b2(w1) genes and is probably a recombinant between d and w1 haplotypes. The hemoglobin containing the W1 phenotype showed oxygen-binding properties identical with those of the hemoglobins containing D and P phenotypes. |
