| First Author | Zammit DJ | Year | 2002 |
| Journal | Mol Cell Biol | Volume | 22 |
| Issue | 3 | Pages | 946-52 |
| PubMed ID | 11784869 | Mgi Jnum | J:73972 |
| Mgi Id | MGI:2157257 | Doi | 10.1128/MCB.22.3.946-952.2002 |
| Citation | Zammit DJ, et al. (2002) Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland. Mol Cell Biol 22(3):946-52 |
| abstractText | Thymic shared antigen 1 (TSA-1) is a plasma membrane protein of the Ly-6 superfamily expressed on thymocytes, thymic stromal cells, and other cells of the hematopoietic system. TSA-1 is also expressed in other nonhematopoietic tissues, in particular, embryonic and adult adrenal glands. To address the function of TSA-1, we generated mutant mice in which TSA-1 expression was inactivated by gene targeting. Here we show that deletion of both TSA-1 alleles results in abnormal adrenal gland development and midgestational lethality due to cardiac abnormalities. We also report that TSA-1-deficient adrenal glands have significantly reduced levels of the catecholamines noradrenaline and adrenaline. We conclude that TSA-1 is required for normal embryonic development but that deletion of its expression does not obviously impair lymphoid development. |
