| First Author | Snider L | Year | 2001 |
| Journal | Mol Cell Biol | Volume | 21 |
| Issue | 5 | Pages | 1866-73 |
| PubMed ID | 11238923 | Mgi Jnum | J:159083 |
| Mgi Id | MGI:4441142 | Doi | 10.1128/MCB.21.5.1866-1873.2001 |
| Citation | Snider L, et al. (2001) Inhibition of Tcf3 binding by I-mfa domain proteins. Mol Cell Biol 21(5):1866-73 |
| abstractText | We have determined that I-mfa, an inhibitor of several basic helix-loop-helix (bHLH) proteins, and XIC, a Xenopus ortholog of human I-mf domain-containing protein that shares a highly conserved cysteine-rich C-terminal domain with I-mfa, inhibit the activity and DNA binding of the HMG box transcription factor XTcf3. Ectopic expression of I-mfa or XIC in early Xenopus embryos inhibited dorsal axis specification, the expression of the Tcf3/beta-catenin-regulated genes siamois and Xnr3, and the ability of beta-catenin to activate reporter constructs driven by Lef/Tcf binding sites. I-mfa domain proteins can regulate both the Wnt signaling pathway and a subset of bHLH proteins, possibly coordinating the activities of these two critical developmental pathways. |
