| First Author | Suzuki T | Year | 2017 |
| Journal | J Biol Chem | Volume | 292 |
| Issue | 41 | Pages | 16817-16824 |
| PubMed ID | 28842501 | Mgi Jnum | J:247330 |
| Mgi Id | MGI:5917041 | Doi | 10.1074/jbc.R117.800169 |
| Citation | Suzuki T, et al. (2017) Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress. J Biol Chem 292(41):16817-16824 |
| abstractText | Transcription factor Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. Nrf2 induces the expression of detoxification and antioxidant enzymes and suppresses the induction of pro-inflammatory cytokine genes. Keap1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of Cullin 3-based E3 ubiquitin ligase. Keap1 regulates the activity of Nrf2 and acts as a sensor for oxidative and electrophilic stresses. In this review, we discuss the molecular mechanisms by which the Keap1-Nrf2 system senses and regulates the cellular response to environmental stresses. In particular, we focus on the multiple stress-sensing mechanisms of Keap1 and novel regulatory functions of Nrf2. |
