| First Author | Honda K | Year | 2006 |
| Journal | Immunity | Volume | 25 |
| Issue | 3 | Pages | 349-60 |
| PubMed ID | 16979567 | Mgi Jnum | J:184127 |
| Mgi Id | MGI:5320281 | Doi | 10.1016/j.immuni.2006.08.009 |
| Citation | Honda K, et al. (2006) Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity 25(3):349-60 |
| abstractText | Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system. |
